By AFP
UK - Manchester City's hopes of a trophy this season now rest solely on the FA Cup ahead of Saturday's visit of second-tier Plymouth, while holders Manchester United also desperately need silverware to rescue a miserable campaign.
With Premier League leaders Liverpool, Arsenal, Chelsea and Tottenham already out, the path has been cleared for the Manchester giants, who have faced off in each of the past two finals.
Brighton, Newcastle and Crystal Palace are among the other clubs who are dreaming of glory come Wembley on May 17.
Here, AFP Sport looks at the pick of the ties from the fifth round this weekend:
(Ugandan times indicated)
Crystal Palace v Millwall (Saturday 3:15pm)
Twice FA Cup runners-up, Palace have never won a major trophy but are coming into form at the right time if they are to reach Wembley this year.
Oliver Glasner's men have won seven of their last nine games in all competitions, most recently thrashing Aston Villa 4-1 in midweek.
Jean-Phillippe Mateta's streak of eight goals in nine games has helped the Eagles soar clear of any relegation trouble and up to 12th in the Premier League.
Now they face a local derby against Championship side Millwall, who are keen to spoil the ambitions of their south London rivals.
Man City v Plymouth (Saturday 8:30pm)
Plymouth were the story of the fourth road as they stunned Liverpool 1-0 at Home Park.
Argyle's reward is a trip to the Etihad and a shot at another monumental shock.
Plymouth boss Miron Muslic has become an internet sensation after clips of his inspirational team talks went viral and is looking forward to coming up against his coaching idol Pep Guardiola.
"It's the biggest honour in my life," said Muslic.
"I'm very much looking forward to shaking his hand and telling him that he's a giant of our sport and a huge, huge role model for every single coach in the world."
Man United are the FA Cup defending champions, having beaten Man City 2-1 in the final last season.